Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis Citation
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Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis
BACKGROUND The human intestine is host to an enormously complex, diverse, and vast microbial community-the gut microbiota. The gut microbiome plays a profound role in metabolic processing, energy production, immune and cognitive development, epithelial homeostasis, and so forth. However, the composition and diversity of the gut microbiome can be readily affected by external factors, which raise...
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BACKGROUND There is growing recognition of the significance of the gut microbiome to human health, and the association between a perturbed gut microbiome with human diseases has been established. Previous studies also show the role of environmental toxicants in perturbing the gut microbiome and its metabolic functions. The wide agricultural use of diazinon, an organophosphate insecticide, has r...
متن کاملGut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.
Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which are frequently associated with different patterns of arsenic metabolism. Several...
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itself. In turn, ingested inorganic arsenic—the more toxic form of the metal—has been shown to change the composition of the gut community. Researchers exploring this newer angle report in EHP that arsenic exposure appears to alter not only the composition of the gut microbiome but also the metabolites it produces. Study leader Kun Lu of the University of Georgia, Athens, and colleagues exposed...
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Microorganisms inhabiting human gastro-intestinal tract exceed the overall number of eukaryotic cells of about one order of magnitude [1–4]. Among the estimated 500–1,000 species [3], the majority has an unknown function, is neither beneficial nor harmful to host and represents the so-called ‘‘normal flora’’ or ‘‘microbiota’’ [5]. Noteworthy, the development of ‘‘next-generation’’ sequencing te...
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